Ethylene Oxide Cancer Studies
We have studied breast cancer incidence in a cohort of 7576 women employed for at least one year and exposed for an average 107 years while working in commercial sterilization facilities. ETO causes mammary tumors in mice and has been associated with breast cancer incidence in one small epidemiologic study.
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Ethylene oxide is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans including epi-demiological studies and studies on mechanisms of carcinogenesis.
Ethylene oxide cancer studies. In smaller amounts ethylene oxide is used as a pesticide and a sterilizing agent. How likely is ethylene oxide to cause cancer. It is manufactured from ethylene and used primarily as a chemical intermediate in the manufacture of ethylene glycol.
Studies show that long-term exposure to ethylene oxide can cause cancers of the white blood cells in humans including non-Hodgkin lymphoma myeloma and lymphocytic leukemia according to the EPA. Humans are most likely to inhale or ingest EtO on the job. EtO is a gas used to sterilize medical instruments and treat spices among other uses.
In a study of chemical workers exposed to ethylene oxide at two plants in the USA the mortality rate from lymphatic and haematopoietic cancer was elevated but the excess was confined to a small subgroup with only occasional low-level exposure to ethylene oxide. In 1959 Dr Lars Ehrenberg and a coworker warned the Swedish authorities that ethylene oxide a common chemical constituted a potential cancer hazard. Ethylene oxide is considered in the same category as asbestos.
Critically both noted that the epidemiological evidence based on lymphoid and breast cancers was limited but that the evidence in animal studies was sufficient and extensive respectively and that EtO is genotoxic. Ethylene oxide EO CAS no. However these data are not considered conclusive.
The results of an updated meta-analysis of the findings from 10 unique EO study. It is used primarily to produce other chemicals including antifreeze. In addition limited epidemiologic investigations at two worksites provide evidence that excess risk of cancer.
Studies have been conducted to evaluate the carcinogenicity of ethylene oxide in rats and mice that inhaled ethylene oxide. Summary of epidemiological results on ethylene oxide and female breast. There has been widespread recognition of the mutagenic potential of ethylene oxide and recent evidence demonstrates adverse reproductive effects in mammals which also are of public health concern.
The National Institute for Occupational Safety and Health NIOSH conducted two studies to examine the health effects from exposure to ethylene oxide EtO. Ethylene oxide EtO is a gas at room temperature. It also increases the risk of breast cancer in women.
In this study ethylene oxide was associated with increases in leukemia in female rats and peritoneal mesotheliomas malignant tumors in male rats. Six other studies in the chemical industry two in Sweden one in the United Kingdom one in Italy one in the USA and one in. At room temperature ethylene oxide is a flammable colorless gas with a sweet odor.
What Happens When Youre Exposed to Ethylene Oxide. Ethylene oxide ETO is a sterilant gas considered to be a human carcinogen due primarily to excess hematopoietic cancer in exposed cohorts. Ethylene oxide was first listed in the Fourth Annual Report on Car-cinogens in 1985 as reasonably anticipated to be a human carcinogen.
An updating of three small Swedish cohorts comprising 709 employees revealed 33 deaths from cancer. Twenty years later the first epidemiological study and case reports were published indicating an increased cancer risk after occupational exposure to ethylene oxide. The ability of ethylene oxide to damage DNA makes it an effective sterilizing agent but also accounts for its cancer-causing activity.
In tandem with the new scientific understanding there have been evolutionary changes in regulatory risk assessment guidelines that encourage flexibility and greater use of scientific information. Ethylene oxide EtO is a highly reactive chemical used as a sterilizing agent and a feedstock for producing other chemicals. To conduct a systematic literature review and meta-analysis of studies of lympho-hematopoietic cancers LHC and breast cancer risk among persons occupationally exposed to ethylene oxide EO.
Companies that use EtO should in theory take precautions to control their EtO. More and more cases showing that workers exposed to ethylene oxide get leukemia and gastric cancer. It has been proved to cause lung cancer mesothelioma and many other cancers.
EtO exposure has been reported in some human and animal studies to be associated with cancers of the blood. Ethylene oxide EO research has significantly increased since the 1980s when regulatory risk assessments were last completed on the basis of the animal cancer chronic bioassays. The weight of evidence from the epidemiologic laboratory animal and mechanistic studies supports a conclusion that EtO is carcinogenic in humans with the strongest human evidence linking EtO.
EO is used primarily as an intermediate in the EO is used primarily as an intermediate in the Ethylene oxide and risk of lympho-hematopoietic cancer and breast cancer. The International Agency for Research on Cancer IARC and the United States Environmental Protection Agency USEPA classified EtO as a known human carcinogen12Critically both noted that the. The International Agency for Research on Cancer IARC and the United States Environmental Protection Agency USEPA classified ethylene oxide EtO as a known human carcinogen.
Because ethylene oxide destroys DNA it can increase the risk of certain cancers. Epidemiological studies of ethylene oxide and human cancerlymphohematopoietic cancer results. EtO has also been reported in some studies to be.
For example asbestos is a known human carcinogen. It is also used as a sterilizing agent for medical equipment and a fumigating agent for spices. How likely is ethylene oxide to cause cancer.
75-21-8 is a highly reactive chemical produced in large volumes. A systematic literature review and meta-analysis springermedizinde.
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